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MOTS-c is encoded in the mitochondrial genome itself, which is why it is studied as part of a distinct signalling class mitochondrial-derived peptides rather than alongside conventional nuclear-encoded peptides
In contrast, cyanocobalamin, a synthetic form of B12, must be converted into Methylcobalamin or adenosylcobalamin in the body before it can be used
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Source: Awosemo et al., Journal of Pharmaceutical and Biomedical Analysis, 2021
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